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It is troublesome if not inconceivable to precisely assess which novel coronavirus vaccine candidates in medical testing are more likely to be the most secure and only. For probably the most half, all we have now to go on at this level are preliminary outcomes from early-stage medical research. Whereas a number of candidates look like promising, it is nonetheless too quickly to know simply how effectively they will work in bigger part Three trials.

Nonetheless, there may be one technique to examine the vaccine candidates that is far more concrete: Have a look at how a lot cash they’ve attracted in improvement funding and provide agreements. Listed here are the COVID-19 vaccine makers which are profitable the cash recreation thus far, with greater than $1 billion in funding lined up.

$100 bills falling from the sky, each with a surgical mask on Ben Franklin's face

Picture supply: Getty Pictures.

1. Sanofi/GlaxoSmithKline

Sanofi (NASDAQ:SNY) and GlaxoSmithKline (NYSE:GSK) take the highest honors. Simply final week, the 2 drugmakers introduced that the U.S. authorities will present funds of as much as $2.1 billion for creating their protein-based, adjuvanted coronavirus vaccine candidate. Sanofi and GSK will present 100 million doses initially, assuming all goes effectively in medical testing.

What’s actually stunning about Sanofi and GSK rating No. 1 is that their COVID-19 vaccine candidate hasn’t even begun a medical trial but. Sanofi is taking the lead position in creating the experimental vaccine. The large drugmaker hopes to start out a part half research in September.

The U.S. deal might develop into a bigger one sooner or later, with the choice for the U.S. to purchase an extra 500 million doses of the Sanofi/GSK vaccine. Sanofi and GSK are additionally in talks with the European Fee and the governments of different international locations about probably supplying COVID-19 vaccine doses.

2. Novavax

Novavax (NASDAQ:NVAX) ranks No. 2 by way of funding amongst all drugmakers creating COVID-19 vaccine candidates. To this point, the clinical-stage biotech has obtained commitments of almost $2.05 billion for its coronavirus vaccine candidate, NVX-CoV2373.

Novavax first obtained $Four million in March from the Coalition for Epidemic Preparedness Improvements (CEPI) to assist early-stage testing of the corporate’s COVID-19 vaccine candidate. In Could, CEPI upped its funding dedication to $388 million. This extra money assisted Novavax’s part 2 improvement of NVX-CoV2373. It additionally helped the biotech scale up its manufacturing of the vaccine and improve the manufacturing of its Matrix-M adjuvant.

In June, the U.S. Division of Protection awarded Novavax a $60 million contract, with the corporate agreeing to produce 10 million doses of NVX-CoV2373 to the navy if the vaccine obtained Emergency Use Authorization (EUA) from the Meals and Drug Administration. However the actually huge prize got here in July, when the U.S. authorities’s Operation Warp Pace awarded $1.6 billion to Novavax to finish late-stage improvement of its COVID-19 vaccine candidate, increase its manufacturing capability, and provide 100 million doses of NVX-CoV2373 to the US.

3. Pfizer/BioNTech

Pfizer (NYSE:PFE) and BioNTech (NASDAQ:BNTX) are available shut behind Novavax. The 2 companions have scored not less than $1.95 billion from a provide cope with the U.S. authorities.

On July 22, Pfizer and BioNTech introduced a cope with the U.S. Division of Well being and Human Companies (HHS) and the U.S. Division of Protection. In trade for $1.95 billion, the 2 firms agreed to produce 100 million doses of the lead COVID-19 vaccine candidate developed within the firms’ BNT162 program (pending FDA approval or an EUA). The settlement additionally offers the U.S. authorities an choice to purchase one other 500 million doses of the vaccine.

Pfizer and BioNTech arguably deserve a better spot. The 2 companions additionally secured a provide deal in July with the UK to produce 30 million doses of their COVID-19 vaccine candidate. Nonetheless, the monetary phrases of this settlement weren’t introduced.

4. AstraZeneca

AstraZeneca (NYSE:AZN) runs neck-and-neck with Pfizer and BioNTech within the coronavirus-vaccine cash recreation. The British drugmaker has hauled in funding of not less than $1.95 billion thus far for AZD1222, the COVID-19 vaccine candidate that it teamed up with the College of Oxford to develop.

A lot of this quantity got here from a $1.2 billion dedication from the Biomedical Superior Analysis and Improvement Authority (BARDA) in Could. The funds will assist AstraZeneca advance medical research of AZD1222 and scale up manufacturing for the vaccine. AstraZeneca agreed to produce not less than 300 million doses to the U.S., assuming the vaccine wins FDA approval or EUA.

AstraZeneca additionally signed a $750 million cope with CEPI and public-private well being partnership Gavi in June. These funds went towards supporting the manufacturing and distribution of 300 million doses of AZD1222.

Like Pfizer and BioNTech, AstraZeneca might simply rank greater on the record. Nonetheless, the monetary phrases of its different provide offers, with the Serum Institute of India and Europe’s Inclusive Vaccines Alliance, weren’t disclosed.

Honorable point out

There’s additionally a drugmaker that deserves an honorable point out. Moderna (NASDAQ:MRNA) has obtained as a lot as $955 million in funding from BARDA to assist the event of its COVID-19 vaccine candidate mRNA-1273.

By way of inventory efficiency thus far this yr, although, Moderna is effectively forward of all the different huge drugmakers profitable the COVID-19 vaccine cash recreation: The biotech inventory is up greater than 300%. Nonetheless, that is nonetheless approach behind Novavax’s year-to-date achieve of shut to three,500%.