New Human ‘Organ’ That Will Protect A Vital Tissue Which Is Identifying: Hello, Everyone Today I am going to share some exciting facts on the New human ‘organ’ that will protect a vital tissue which is identifying.
New human ‘Organ’ That Will Protect A Vital Tissue Which Is Identifying
The findings, published in the journal Scientific Reports, has implications for the function of all organs, most tissues and the mechanisms of most major diseases.
Researchers from the New York University in the US showed that layers of the body long thought to be dense, connective tissues – below the skin’s surface, lining the digestive tract, lungs and urinary systems, and surrounding arteries, veins, and the fascia between muscles – are instead interconnected fluid-filled compartments.
This series of spaces, supported by a meshwork of strong (collagen) and flexible (elastin) connective tissue proteins, may act like shock absorbers that keep tissues from tearing as organs, muscles, and vessels squeeze pump and pulse as part of the daily function.
The finding that this layer is a highway of moving fluid may explain why cancer that invades it becomes much more likely to spread.
It is the newfound network the source of lymph, the fluid vital to the functioning of immune cells that generate inflammation.
Furthermore, the cells that reside in the space, and collagen bundles they line, change with age and may contribute to the wrinkling of skin, the stiffening of limbs, and the progression of fibrotic, sclerotic and inflammatory diseases.
The field has long known that more than half the fluid in the body resides within cells, and about a seventh inside the heart, blood vessels, lymph nodes, and lymph vessels. The remaining liquid is “interstitial,” and the current study is the first to define the interstitium as an organ in its own right, and as one of the largest of the body, researchers says.
No one saw these spaces before because of the medical field’s dependence on the examination of fixed tissue on microscope slides, believed to offer the most accurate view of biological reality.
Scientists prepare fabric this examination by treating it with chemicals, slicing it thinly, and dying it to highlight key features. The “fixing” process makes vivid details of cells and structures but drains away any fluid.
The current research team found that the removal of fluid as slides are made causes the connective protein meshwork surrounding once fluid-filled compartments to pancake, like the floors of a collapsed building.
“This fixation artefact of collapse has made a fluid-filled tissue type throughout the body appear solid in biopsy slides for decades, and our results correct for this to expand the anatomy of most tissues,” says Neil Theise, a professor at NYU.
“This finding has potential to drive dramatic advances in medicine, including the possibility that the direct sampling of interstitial fluid may become a powerful diagnostic tool,” Theise says.
The study findings are on the newer technology called Probe-based confocal laser endomicroscopy, which combines the slender camera-toting probe traditionally snaked down the throat to view the insides of organs (an endoscope) with a laser that lights up tissues, and sensors that analyse the reflected fluorescent patterns. It offers a microscopic view of living tissues instead of fixed ones.
For the study, researchers collected tissue specimens of bile ducts during twelve cancer surgeries that were removing the pancreas and the bile duct. Minutes before clamping off blood flow to the target tissue, patients underwent confocal microscopy for live tissue imaging.
Once the team recognised this new space in images of bile ducts, they quickly realised it throughout the body, wherever tissues moved or were compressing through the force. The cells lining the area are also unusual, perhaps responsible for creating the supporting collagen bundles around them, researchers say.
The cells may also be mesenchymal stem cells, says Theise, which are known to be capable of contributing to the formation of scar tissue seen in inflammatory diseases.
Lastly, the protein bundles seen in the space are likely to generate electrical current as they bend with the movements of organs and muscles, and may play a role in techniques like acupuncture, he says.
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